Bailleul S, Couderc R, Rossignol C, Fermanian J, Boutouchent F, Farnier M A, Etienne J
Department of Biochemistry, Hôpital Tenon, Paris, France.
Clin Chem. 1995 Feb;41(2):241-5.
The relation between lipoprotein(a) [Lp(a)], apolipoprotein (apo) E phenotypes, cholesterol, triglycerides, apo A-I, apo B, and a family history of atherosclerosis or risk factors was studied in 2- and 4-year-old French Caucasian children (n = 499). Lp(a) concentrations were distributed in a typical skewed manner and were found to be an independent lipid variable. The distribution of apo E phenotypes did not differ by gender. Cholesterol and apo B were under apo E phenotype control; Lp(a) was not. A significant positive relation was found between Lp(a) concentrations and the number of parental risk factors. Children whose grandparents had a history of cardiovascular disease had Lp(a) concentrations shifted towards higher values. Measurement of Lp(a) in children may help to identify those at an increased risk of atherosclerotic disease, especially when their parents have at least two relevant risk factors.
我们对499名2岁和4岁的法国白种儿童进行了研究，以探讨脂蛋白(a)[Lp(a)]、载脂蛋白(apo)E表型、胆固醇、甘油三酯、载脂蛋白A-I、载脂蛋白B与动脉粥样硬化家族史或危险因素之间的关系。Lp(a)浓度呈典型的偏态分布，是一个独立的脂质变量。apo E表型的分布不存在性别差异。胆固醇和载脂蛋白B受apo E表型控制；Lp(a)则不受其控制。Lp(a)浓度与父母的危险因素数量之间存在显著正相关。祖父母有心血管疾病史的儿童，其Lp(a)浓度较高。检测儿童的Lp(a)可能有助于识别动脉粥样硬化疾病风险增加的儿童，尤其是当他们的父母至少有两个相关危险因素时。
