Lansdorp P M
Terry Fox Laboratory, British Columbia Cancer Agency, Department of Medicine, University of British Columbia, Vancouver, Canada.
Exp Hematol. 1995 Mar;23(3):187-91.
The observation that colony-forming unit-spleen (CFU-S) cells can be found in the yolk sac, fetal liver, and various hematopoietic tissues in adult mice has contributed to the concept that "stem cells" represent a single type of immortal cell that is present at variable numbers in tissues at different stages of development. However, more recent studies have shown dramatic changes in various functional properties of purified "candidate" stem cells during ontogeny. Together with previous studies documenting developmental changes in early hematopoietic cells and observations showing a decrease in the mean telomere length of chromosomes in hematopoietic cells during ontogeny, these findings are difficult to reconcile with the concept of a stem cell as an immortal and invariable cell type. In this minireview, some developmental aspects of stem cell biology are discussed in the context of stem cell definitions and transplantation biology.
在成年小鼠的卵黄囊、胎肝及各种造血组织中可发现脾集落形成单位（CFU-S）细胞，这一观察结果促使人们形成了这样的概念：“干细胞”代表一种单一类型的永生细胞，在发育的不同阶段，其在组织中的数量各不相同。然而，最近的研究表明，纯化的“候选”干细胞在个体发育过程中各种功能特性发生了显著变化。结合先前记录早期造血细胞发育变化的研究以及显示造血细胞在个体发育过程中染色体平均端粒长度减少的观察结果，这些发现难以与干细胞作为一种永生且不变的细胞类型这一概念相协调。在本综述中，将在干细胞定义和移植生物学的背景下讨论干细胞生物学的一些发育方面。
