Petrini M, Galimberti S, Sabbatini A, Bianchi F, Bernardini N, Dolfi A, Lupetti M
Cattedra di Istologia ed Embriologia Istituto di Anatomia Umana normale, Pisa, Italy.
Experientia. 1995 Feb 15;51(2):137-40. doi: 10.1007/BF01929357.
The presence of a multidrug resistance (MDR) related protein, P-170, in normal and pathological lymphoid cells has been described. The present report evaluates the expression of the mdr 1 gene by using the reverse Polymerase Chain Reaction (PCR) on cells obtained from the thymus and bursa of chicken embryos starting from day 12 until hatching. Results show that the thymic cells are positive from day 12 to the end of the observation period. In contrast, mdr mRNA was detected in the bursa from day 14 to day 17 of embryonic life. Possible relationships between the expression of mdr and the development of T and B lymphocytes are discussed.
已经报道了正常和病理性淋巴细胞中存在与多药耐药（MDR）相关的蛋白质P - 170。本报告通过逆转录聚合酶链反应（PCR）评估了从第12天到孵化期鸡胚胸腺和法氏囊中获得的细胞中mdr 1基因的表达。结果显示，从第12天到观察期结束胸腺细胞呈阳性。相比之下，在胚胎期第14天到第17天在法氏囊中检测到mdr mRNA。讨论了mdr表达与T和B淋巴细胞发育之间的可能关系。
