[慢性丙型病毒性肝炎中肝脏非特异性抗细胞器抗体的患病率及意义]
[Prevalence and significance of non-specific anti-organelle antibodies of the liver in chronic viral hepatitis C].
作者信息
Borotto E, Lunel F, Valla D, Abuaf N, Perrin M, Bousquet J C, Opolon P, Homberg J C
机构信息
Service d'Hépato-Gastroentérologie, Groupe Hospitalier Pitié-Sqalpêtrière, Paris.
出版信息
Gastroenterol Clin Biol. 1994;18(10):813-8.
OBJECTIVES
The aim of this study was to evaluate the prevalence and the clinical signification of non organ specific autoantibodies in chronic hepatitis C.
METHODS
We studied retrospectively 158 consecutive patients (97 with chronic hepatitis C, 24 with chronic hepatitis B, 67 with alcoholic cirrhosis) and 100 blood-donors.
RESULTS
The prevalence of anti-nuclear and anti-smooth muscle antibodies was lower in blood donors than in patients (P < 0.001), but was comparable among the 3 groups of patients. The anti-liver-kidney microsome type 1 antibodies were detected only in patients with chronic hepatitis C (6%). The serum gammaglobulin level was significantly higher in patients with hepatitis C and anti-nuclear antibody titers > or = 1/50. The anti-smooth muscle antibodies detected in patients with hepatitis C had no anti-actin specificity. The response to interferon was not related to the detection of non organ specific autoantibodies before treatment.
CONCLUSION
Anti-nuclear or anti-smooth muscle antibodies are not characteristic of hepatitis C virus infection.
目的
本研究旨在评估慢性丙型肝炎中非器官特异性自身抗体的患病率及其临床意义。
方法
我们回顾性研究了158例连续患者（97例慢性丙型肝炎患者、24例慢性乙型肝炎患者、67例酒精性肝硬化患者）以及100名献血者。
结果
献血者中抗核抗体和抗平滑肌抗体的患病率低于患者（P < 0.001），但在三组患者中患病率相当。仅在慢性丙型肝炎患者中检测到抗肝肾微粒体1型抗体（6%）。丙型肝炎且抗核抗体滴度≥1/50的患者血清γ球蛋白水平显著更高。丙型肝炎患者中检测到的抗平滑肌抗体无抗肌动蛋白特异性。对干扰素的反应与治疗前非器官特异性自身抗体的检测无关。
结论
抗核或抗平滑肌抗体并非丙型肝炎病毒感染的特征性表现。
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