人表皮生长因子对小鼠被动回避和习惯化学习的影响。

Effects of human epidermal growth factor on passive avoidance and habituation learning in mice.

Ukai M, Miura M, Kameyama T

Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.

Gen Pharmacol. 1994 Oct;25(6):1157-62. doi: 10.1016/0306-3623(94)90132-5.

Abstract

Human epidermal growth factor (hEGF:0.02-2.0 micrograms) did not affect passive avoidance response or habituation learning when given before or immediately after training, or before retention. 2. hEGF (0.02-2.0 micrograms) failed to influence the scopolamine- or electroconvulsive shock-induced shortening of step-down latency in passive avoidance response when given before or immediately after training, or before retention. 3. These results suggest that the acute administration of hEGF does not affect memory processes as indexed by passive avoidance or habituation learning in normal or amnesic mice.

摘要

人表皮生长因子（hEGF：0.02 - 2.0微克）在训练前、训练后立即给予或在记忆保持前给予时，均不影响被动回避反应或习惯化学习。2. hEGF（0.02 - 2.0微克）在训练前、训练后立即给予或在记忆保持前给予时，未能影响东莨菪碱或电惊厥休克诱导的被动回避反应中步下潜伏期缩短。3. 这些结果表明，急性给予hEGF不影响正常或失忆小鼠中以被动回避或习惯化学习为指标的记忆过程。