Angelucci M E, Vital M A, Cesário C, Zadusky C R, Rosalen P L, Da Cunha C
Laboratório de Fisiologia e Farmacologia do SNC, Dep. Farmacologia, UFPR, Curitiba PR, Brazil.
Eur J Pharmacol. 1999 Jun 4;373(2-3):135-40. doi: 10.1016/s0014-2999(99)00225-3.
In the present investigation we studied the effect of caffeine on memory task inhibitory avoidance and habituation to a new environment. Caffeine impaired retention scores in mice submitted to inhibitory avoidance and habituation when administered 30 min before training at the doses of 10-30 mg/kg. These effects cannot be explained by state-dependency since the administration of caffeine 30 min before the test session did not reverse the effect of pre-training caffeine administration, but can more probably be explained by an impairment in the acquisition or by interference with attentional processes. On the other hand, caffeine improved the inhibitory avoidance (but not habituation) retention scores when administered immediately after the training or 30 min before the test session at the doses of 1-30 mg/kg or 3-10 mg/kg, respectively. These results suggest that caffeine differentially affects the different stages of memory processing and that this effect depends on particularities of the memory task under study.
在本研究中，我们研究了咖啡因对记忆任务抑制性回避和对新环境的习惯化的影响。当在训练前30分钟以10 - 30毫克/千克的剂量给予小鼠时，咖啡因损害了接受抑制性回避和习惯化训练的小鼠的记忆保持分数。这些效应不能用状态依赖性来解释，因为在测试前30分钟给予咖啡因并没有逆转训练前给予咖啡因的效应，而更可能是由获取过程受损或对注意力过程的干扰来解释。另一方面，当分别以1 - 30毫克/千克或3 - 10毫克/千克的剂量在训练后立即给予或在测试前30分钟给予时，咖啡因改善了抑制性回避（但不是习惯化）的记忆保持分数。这些结果表明，咖啡因对记忆加工的不同阶段有不同的影响，并且这种影响取决于所研究的记忆任务的特殊性。
