Gupta G S, Malhotra R
Department of Biophysics, Panjab University, Chandigarh, India.
Indian J Biochem Biophys. 1994 Dec;31(6):480-5.
Hyper-immunization of male mice with human LDH-C4 evoked autoimmune reactions illustrated by the loss of LDH activity, associated histopathological changes in testes and epididymis and induction of sterility in mice. This was substantiated by the altered morphology of sperm mitochondria and plasma membrane, and by reduced number of cytoplasmic droplets as observed by electron microscopy. However, the presence of lymphoblasts and other lymphoid cells in testes indicated that the testicular damage is accentuated by activated T lymphocytes. It is concluded that immunization with human LDH-C4 produces lesions in mouse testis and epididymis, which are similar to experimentally induced autoimmune orchitis.
用人乳酸脱氢酶C4对雄性小鼠进行超免疫会引发自身免疫反应，表现为乳酸脱氢酶活性丧失、睾丸和附睾相关的组织病理学变化以及小鼠不育。通过电子显微镜观察到的精子线粒体和质膜形态改变以及细胞质滴数量减少证实了这一点。然而，睾丸中存在淋巴母细胞和其他淋巴细胞表明活化的T淋巴细胞加剧了睾丸损伤。得出的结论是，用人乳酸脱氢酶C4免疫会在小鼠睾丸和附睾中产生病变，这些病变与实验诱导的自身免疫性睾丸炎相似。
