Biswas P K, Ray S, Dasbiswas A, Lhila S, Chatterjee S S, Maity A K
R.M.O. Cardiology, S.S.K.M. Hospital, Calcutta.
J Assoc Physicians India. 1994 Oct;42(10):785-8.
160 patients with first attack of acute myocardial infarction (AMI), admitted within 6 hours after onset of chest pain, were divided into two groups--80 receiving intravenous streptokinase (IVSK, Gr. I) an 80 being treated without IVSK (GR. II). They were studied for pre-discharge (12.5 +/- 2.5 days-post admission) echocardiographic LV function. Gr. I pts received 1.5 million units of IVSK within 6 hrs of onset of chest pain, alongwith beta-blockers, aspirin and heparin unless contraindicated. Gr. II received all these except IVSK alongwith conventional therapy. Highly significant (P < 0.001) improvement was noted in the end-diastolic volume (EDV), end-systolic volume (ESV), Ejection fraction (EF) and regional wall motion score (RWMS) in the anterior wall (AW) AMI group when treated early with IVSK. In the inferior wall (IW) AMI group significant decrease was observed in the EDV and ESV (P < 0.001) and RWMS (P < 0.05), but the difference was not statistically significant for EF. Early high-dose short term IVSK infusion is thus associated with highly significant improvement in LV functions--regional as well as global--especially in AW AMI; in IWAMI the improvement is less marked.
160例首次发作急性心肌梗死（AMI）且在胸痛发作后6小时内入院的患者被分为两组，一组80例接受静脉注射链激酶（IVSK，I组），另一组80例不接受IVSK治疗（II组）。对他们进行出院前（入院后12.5±2.5天）超声心动图左心室功能研究。I组患者在胸痛发作后6小时内接受150万单位IVSK治疗，同时除非有禁忌证，还接受β受体阻滞剂、阿司匹林和肝素治疗。II组接受除IVSK外的所有这些治疗以及常规治疗。早期用IVSK治疗时，前壁（AW）AMI组的舒张末期容积（EDV）、收缩末期容积（ESV）、射血分数（EF）和室壁运动评分（RWMS）有极显著（P<0.001）改善。下壁（IW）AMI组的EDV和ESV有显著降低（P<0.001），RWMS也有显著降低（P<0.05），但EF差异无统计学意义。因此，早期大剂量短期IVSK输注与左心室功能（局部和整体）的极显著改善相关，尤其是在AW AMI中；在IW AMI中改善不太明显。
