Goldberg M, Lasfargues J J
Laboratoire de Biologie et Biomatériaux du Milieu Buccal et Osseux, Faculté de Chirurgie Dentaire, Université Paris V, France.
J Dent. 1995 Feb;23(1):15-20. doi: 10.1016/0300-5712(95)90655-2.
The value of the concept of a pulpo-dentinal complex was assessed on human teeth treated according to the ISO test on biological evaluation. The teeth were extracted after 1 or 3 months and examined histologically. Biochemical and biological data available from the dental literature were also re-examined.
During the early development of the tooth, pulp and dentine establish close links and form an undivided organ. However, examination of the tissues at later stages of development casts doubt on the validity of such a concept. Major differences are reviewed in this report between the cells (odontoblasts and heterogeneous pulpal cells) and extracellular matrix (collagens, non-collagenic proteins and phospholipids) located either in the odontoblast-dentine area or in the pulp. It seems also that clear-cut differences are detected during inflammatory and repair processes.
It is concluded that, although the existence of a dentino-pulpal reaction cannot be denied, the concept of a pulpo-dentinal complex is an oversimplification and should be revisited. This may have implications in the evaluation of restorative treatments and in the design of a tissue repair strategy.
根据国际标准化组织（ISO）生物评价试验对人牙进行处理，评估牙髓 - 牙本质复合体概念的价值。在1个月或3个月后拔除牙齿并进行组织学检查。还重新审视了牙科文献中可用的生化和生物学数据。
在牙齿早期发育过程中，牙髓和牙本质建立紧密联系并形成一个不可分割的器官。然而，对发育后期组织的检查对这一概念的有效性提出了质疑。本报告回顾了位于成牙本质细胞 - 牙本质区域或牙髓中的细胞（成牙本质细胞和异质性牙髓细胞）以及细胞外基质（胶原蛋白、非胶原蛋白和磷脂）之间的主要差异。在炎症和修复过程中似乎也检测到明显差异。
得出的结论是，虽然不能否认牙本质 - 牙髓反应的存在，但牙髓 - 牙本质复合体的概念过于简单化，应重新审视。这可能对修复治疗的评估和组织修复策略的设计产生影响。
