Hoke C H, Egan J E, Sjogren M H, Sanchez J, DeFraites R F, MacArthy P O, Binn L N, Rice R, Burke A, Hill J
Walter Reed Army Institute of Research, Washington, DC.
J Infect Dis. 1995 Mar;171 Suppl 1:S53-60. doi: 10.1093/infdis/171.supplement_1.s53.
Military personnel are an important target population for hepatitis A immunization. Soldiers are often given vaccines by jet injector and may be required to receive multiple vaccines at one time. Formalin-inactivated hepatitis A vaccine containing 360 ELISA units of antigen was evaluated at Fort Campbell. Volunteers received vaccine at 0, 1, and 6 months as follows: group 1, hepatitis A vaccine by needle; group 2, hepatitis A vaccine by jet injector; group 3, hepatitis B vaccine by needle; and group 4, both hepatitis vaccines by needle in separate arms. Immune response and reactogenicity were evaluated. After two doses, recipients of vaccine administered by jet injector had a higher prevalence of antibody than those who received vaccine by needle (93% vs. 79%). By the 8th month, the vaccine was 100% immunogenic by either route or with hepatitis B vaccine. No interaction between hepatitis A and B vaccines was detected.
军事人员是甲型肝炎疫苗接种的重要目标人群。士兵通常通过喷射注射器接种疫苗，并且可能需要一次接种多种疫苗。在坎贝尔堡对含360个酶联免疫吸附测定单位抗原的甲醛灭活甲型肝炎疫苗进行了评估。志愿者在0、1和6个月时接种疫苗，分组如下：第1组，通过针头接种甲型肝炎疫苗；第2组，通过喷射注射器接种甲型肝炎疫苗；第3组，通过针头接种乙型肝炎疫苗；第4组，在不同手臂分别通过针头接种两种肝炎疫苗。对免疫反应和反应原性进行了评估。两剂接种后，通过喷射注射器接种疫苗的受种者抗体阳性率高于通过针头接种疫苗的受种者（93%对79%）。到第8个月时，无论通过何种途径接种疫苗或同时接种乙型肝炎疫苗，该疫苗的免疫原性均为100%。未检测到甲型和乙型肝炎疫苗之间存在相互作用。
