Ballmer P E, McNurlan M A, Essen P, Anderson S E, Garlick P J
Department of Medicine, University of Berne, Inselspital, Switzerland.
J Nutr. 1995 Mar;125(3):512-9. doi: 10.1093/jn/125.3.512.
The response of albumin synthesis rates to infusion of either an intravenous nutrient mixture containing adequate nitrogen and energy or an isotonic saline infusion was compared in adult men. In a crossover study, nine healthy male subjects received a short-term (13.5-h) infusion of either the nutrient mixture or the saline solution, and albumin synthesis rates were measured by a stable isotope technique employing [2H5ring]phenylalanine. Fractional rates of albumin synthesis did not differ significantly between treatments (saline, 7.3 +/- 1.0%/d; intravenous nutrients, 7.8 +/- 1.0%/d). The secretion time of albumin was significantly lower with intravenous nutrients infusion than with saline infusion. Plasma albumin concentration as well as prealbumin and transferrin concentrations decreased over time when subjects were infused with either saline or the nutrient solution as a result of dilution rather than a change in synthesis. These results suggest that albumin synthesis rate does not respond to short-term intravenous nutrients.
在成年男性中，比较了白蛋白合成速率对输注含充足氮和能量的静脉营养混合物或等渗盐水的反应。在一项交叉研究中，9名健康男性受试者接受了为期短期（13.5小时）的营养混合物或盐溶液输注，并采用[2H5环]苯丙氨酸的稳定同位素技术测量白蛋白合成速率。各治疗组间白蛋白合成分数率无显著差异（盐水组，7.3±1.0%/天；静脉营养组，7.8±1.0%/天）。静脉输注营养物质时白蛋白的分泌时间显著低于输注盐水时。当受试者输注盐水或营养液时，由于稀释而非合成变化，血浆白蛋白浓度以及前白蛋白和转铁蛋白浓度随时间下降。这些结果表明，白蛋白合成速率对短期静脉营养无反应。
