Ballmer P E, Reichen J, McNurlan M A, Sterchi A B, Anderson S E, Garlick P J
Department of Medicine, University of Berne, Inselspital, Switzerland.
Hepatology. 1996 Jul;24(1):53-9. doi: 10.1002/hep.510240111.
Albumin and fibrinogen synthesis rates were measured in 15 subjects with different clinical stages of postviral cirrhosis and compared with galactose elimination capacity and aminopyrin breath test. Forty-three mg per kg body weight [2H5ring]phenylalanine with an isotopic enrichment of 10 atom% were intravenously injected. [2H5ring]phenylalanine enrichments in the plasma-free phenylalanine and the albumin and fibrinogen isolates were measured by gas chromatography-mass spectrometry. Fractional synthesis rates of albumin were normal in Child A cirrhosis (7.6 +/- 2.2%d), but were lower in both Child B (3.5 +/- 0.8%d) and C (4.5 +/- 2.8%d). Absolute rates of albumin synthesis were (103 +/- 30 mg/kg/d) in the child A group and substantially lower in the Child B (50 +/- 3 mg/kg/d) and C (36 +/- 20 mg/kg/d) group. The average fractional synthesis rate of fibrinogen was 16.7 +/- 7.5%d and the absolute synthesis rate 11.6 +/- 6.4 mg/kg/d. The values of the galactose elimination capacity and the aminopyrin breath test were below the normal range in all patients, gradually decreasing with an increase in the severity of the clinical stage of cirrhosis. Albumin synthesis rates significantly correlated with the Child scores, the galactose elimination capacity, and the aminopyrin breath test, whereas fibrinogen synthesis rates showed no such correlations.
在15例不同临床阶段的病毒后肝硬化患者中测量了白蛋白和纤维蛋白原的合成率，并与半乳糖清除能力和氨基比林呼气试验进行了比较。静脉注射每千克体重43毫克、同位素丰度为10原子%的[2H5环]苯丙氨酸。通过气相色谱 - 质谱法测量无血浆苯丙氨酸以及白蛋白和纤维蛋白原分离物中[2H5环]苯丙氨酸的丰度。Child A级肝硬化患者白蛋白的合成率分数正常（7.6±2.2%/天），但Child B级（3.5±0.8%/天）和C级（4.5±2.8%/天）患者的合成率分数较低。Child A组白蛋白的合成绝对率为（103±30毫克/千克/天），而Child B组（50±3毫克/千克/天）和C组（36±20毫克/千克/天）则显著较低。纤维蛋白原的平均合成率分数为16.7±7.5%/天，绝对合成率为11.6±6.4毫克/千克/天。所有患者的半乳糖清除能力和氨基比林呼气试验值均低于正常范围，并随着肝硬化临床阶段严重程度的增加而逐渐降低。白蛋白合成率与Child评分、半乳糖清除能力和氨基比林呼气试验显著相关，而纤维蛋白原合成率则无此类相关性。
