Sluijmer A V, Heineman M J, De Leeuw R, Evers J L
Department of Obstetrics and Gynaecology, Academisch Ziekenhuis Maastricht, Netherlands.
Maturitas. 1994 Nov;20(1):45-51. doi: 10.1016/0378-5122(94)90100-7.
Gonadotropin levels were determined in 17 postmenopausal women before and after administering a single depot-dose of the GnRH agonist triptorelin. E2 levels of all samples were in the normal (low) postmenopausal range and no differences were found when the patients were grouped according to chronological age, or time after menopause. Pre-GnRH agonist levels of LH and FSH were in the normal (high) postmenopausal range. Two weeks after medication, LH and FSH had decreased to premenopausal levels (P < 0.0001). Eight weeks after medication, LH levels were still low whereas FSH levels had risen significantly again (P < 0.0001). Both LH and FSH levels, however, were still significantly below the serum concentrations before the administration of triptorelin (P < 0.0001). The pre-GnRH agonist level of FSH was significantly higher in women > 67 years old (P < 0.05), as compared to women < 67 years. Two weeks after medication both LH and FSH levels were significantly higher in women more than 15 years after menopause (P < 0.05), as compared to those < 15 years. The same was found for FSH in women > 67 years old. No further significant differences were noted. This study demonstrates a significant decrease of LH and FSH serum levels in postmenopausal women within two weeks after administration of a single depot-dose of the GnRH agonist triptorelin. After eight weeks, in contrast to premenopausal women, both LH and FSH, although rising, were still significantly suppressed.
对17名绝经后女性在单次注射长效促性腺激素释放激素（GnRH）激动剂曲普瑞林前后测定促性腺激素水平。所有样本的雌二醇（E2）水平均在绝经后正常（低）范围内，根据实际年龄或绝经后时间对患者进行分组时未发现差异。GnRH激动剂治疗前促黄体生成素（LH）和促卵泡生成素（FSH）水平在绝经后正常（高）范围内。用药两周后，LH和FSH降至绝经前水平（P < 0.0001）。用药八周后，LH水平仍然较低，而FSH水平再次显著升高（P < 0.0001）。然而，LH和FSH水平仍显著低于注射曲普瑞林前的血清浓度（P < 0.0001）。67岁以上女性GnRH激动剂治疗前的FSH水平显著高于67岁以下女性（P < 0.05）。用药两周后，绝经超过15年的女性LH和FSH水平显著高于绝经不足15年的女性（P < 0.05）。67岁以上女性的FSH情况也是如此。未发现进一步的显著差异。本研究表明，绝经后女性单次注射长效GnRH激动剂曲普瑞林两周内LH和FSH血清水平显著下降。八周后，与绝经前女性不同，LH和FSH虽然有所上升，但仍受到显著抑制。
