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痴呆与阿尔茨海默病。适应症、诊断与治疗。

Dementia and Alzheimer's disease. Indications, diagnosis, and treatment.

作者信息

Golden R

机构信息

Noran Neurological Clinic, Minneapolis.

出版信息

Minn Med. 1995 Jan;78(1):25-9.

PMID:7877576
Abstract

At least 6 million Americans suffer from some form of dementia. More than half of those patients are afflicted with Alzheimer's disease, a progressive, degenerative neurological disorder. Reaching the diagnosis of Alzheimer's, however, is often difficult since Alzheimer's can be accurately diagnosed only after all other options are ruled out. The process is painstaking, but it's also the crucial link in ensuring proper diagnosis and treatment. There's no cure yet for Alzheimer's, but researchers are narrowing in on possible causes of the disease and identifying patients who may be predisposed to developing it. Some of the most compelling research focuses on the presence of one or more of the apolipoprotein E4 genes. Researchers also continue to develop new drugs and physical therapies. In the Twin Cities, several drug studies are underway, and community resources are available to provide Alzheimer's patients and their families with information on everything from support groups to assisted-living arrangements.

摘要

至少600万美国人患有某种形式的痴呆症。这些患者中超过一半患有阿尔茨海默病,这是一种进行性、退行性神经疾病。然而,做出阿尔茨海默病的诊断往往很困难,因为只有在排除所有其他可能性之后才能准确诊断出阿尔茨海默病。这个过程很艰辛,但它也是确保正确诊断和治疗的关键环节。目前还没有治愈阿尔茨海默病的方法,但研究人员正在缩小对该疾病可能病因的研究范围,并识别出可能易患该病的患者。一些最引人注目的研究集中在一种或多种载脂蛋白E4基因的存在上。研究人员也在继续研发新药物和物理疗法。在双子城,几项药物研究正在进行中,社区资源可用于为阿尔茨海默病患者及其家人提供从支持小组到辅助生活安排等各方面的信息。

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