G蛋白门控性心房钾通道IKACh是由两种内向整流钾通道蛋白构成的异源多聚体。
The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins.
作者信息
Krapivinsky G, Gordon E A, Wickman K, Velimirović B, Krapivinsky L, Clapham D E
机构信息
Department of Pharmacology, Mayo Foundation, Rochester, Minnesota 55905.
出版信息
Nature. 1995 Mar 9;374(6518):135-41. doi: 10.1038/374135a0.
Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K+) channel, IKACh. Activated muscarinic receptors stimulate IKACh via the G-protein beta gamma-subunits. It has been assumed that the inwardly rectifying K(+)-channel gene, GIRK1, alone encodes IKACh. It is now shown that IKACh is a heteromultimer of two distinct inwardly rectifying K(+)-channel subunits, GIRK1 and a newly cloned member of the family, CIR.
心率部分通过乙酰胆碱依赖性激活心脏钾（K+）通道IKACh而减慢。活化的毒蕈碱受体通过G蛋白βγ亚基刺激IKACh。一直以来人们认为内向整流K+通道基因GIRK1单独编码IKACh。现在研究表明，IKACh是由两个不同的内向整流K+通道亚基GIRK1和该家族新克隆的成员CIR组成的异源多聚体。
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