Yamamoto T, Shimura T, Sakai N, Ozaki N
Department of Behavioral Physiology, Faculty of Human Sciences, Osaka University, Japan.
Physiol Behav. 1994 Dec;56(6):1197-202. doi: 10.1016/0031-9384(94)90366-2.
The distribution of evoked expression of the proto-oncogene c-fos was immunohistochemically examined in the parabrachial nucleus (PBN) of water-deprived rats after free ingestion of palatable liquids, after intra-oral infusion of aversive taste solutions including various bitter substances, and after an intraperitoneal injection of LiCl. C-fos immunoreactive neurons (c-fos neurons) were densely packed in the external lateral subnucleus (els), external medial subnucleus (ems), dorsal lateral subnucleus (dls), central lateral subnucleus (cls), and the central medial subnucleus (cms) depending on the kind of stimulation. The rostral part of the els may be related to general visceral inputs; the caudal part of the els, negative hedonics or aversive behavior; the dls, positive hedonics or ingestive behaviour. Both the ems and the els may be related to taste information for bitter tasting compounds and HCl; the cls, for sucrose and saccharin; and the cms, for NaCl.
在自由摄取美味液体后、经口输注包括各种苦味物质在内的厌恶性味觉溶液后以及腹腔注射氯化锂后，采用免疫组织化学方法检测了缺水大鼠臂旁核（PBN）中原癌基因c-fos诱发性表达的分布情况。根据刺激类型的不同，c-fos免疫反应性神经元（c-fos神经元）密集分布于外侧外侧亚核（els）、外侧内侧亚核（ems）、背外侧亚核（dls）、中央外侧亚核（cls）和中央内侧亚核（cms）。els的吻侧部分可能与一般内脏传入有关；els的尾侧部分与负性享乐或厌恶性行为有关；dls与正性享乐或摄食行为有关。ems和els可能都与苦味化合物和盐酸的味觉信息有关；cls与蔗糖和糖精有关；cms与氯化钠有关。
