Nabrzyski M
Katedry i Zakładu Bromatologii Wydziału Farmaceutycznego Akademii Medycznej, Gdańsku.
Rocz Panstw Zakl Hig. 1994;45(1-2):1-12.
The present approach to the assessment of carcinogens in food is described in the light of a literature review. In accordance with Delaney clause, these compounds should not be found in food. The advances in analytical methods have shown, however, that it is not possible to avoid the presence of trace amounts of carcinogens, natural as well as synthetic. On the basis of the maximal tolerated dose (MTD) established in animal studies the power of cancerogenic activity of many compounds was determined as expressed by the dose producing cancer development in 50% of the experimental animals. This dose has the symbol TD50, analogously to the LD50 symbol used in toxicology. On the basis of these doses a trial is presented of ranking carcinogenicity++ using a new index HERP which expressed the per cent of the amount of a compound taken with food in relation to TD50. Trials are mentioned also of estimating health risk on the basis of evaluation of the risk of malignancy development due to intake of a compound with food, according to the "de minimis" doctrine.
根据文献综述描述了当前食品中致癌物评估方法。按照德莱尼条款，这些化合物不应在食品中被发现。然而，分析方法的进步表明，无法避免痕量致癌物的存在，包括天然的和合成的。基于动物研究确定的最大耐受剂量（MTD），许多化合物的致癌活性强度以在50%实验动物中引发癌症的剂量来确定。该剂量的符号为TD50，类似于毒理学中使用的LD50符号。基于这些剂量，提出了一项使用新指标HERP对致癌性进行分级的试验，HERP表示食物中摄入的化合物量相对于TD50的百分比。还提到了根据“最低风险”原则，基于对因食物摄入化合物而导致恶性肿瘤发生风险的评估来估计健康风险的试验。
