Vardi J
Obstet Gynecol. 1976 Oct;48(4):447-51.
Seventeen placentas from term gestation complicated by toxemia of pregnancy and 17 normal controls were tested by the fluorescent antibody technic. Antisera to normal placental connective tissue and toxemic placental connective tissue were used. The antisera were obtained by the injection into rabbits of placental extracts rich in connective tissue elements from normal and toxemic placentas. The antitoxemic antisera, after absorption with soluble sonic fraction of normal placentas, stained the following elements exclusively in 14 of the 17 placentas: part of the syncytial knots, fibrillar elements in the adventitia of blood vessels, and amorphous deposition of connective tissue. In each of the remaining three placentas at least two of the lesions were observed. The observation of bright fluorescence in part of the syncytiotrophoblasts and the syncytial knots in toxemic placentas led to the suggestion that they arise late in pregnancy during the disease. The thin fibrillar elements and the amorphous deposition of connective tissue were documented in the various developmental stages in toxemic and normal placentas as well. These findings established possible characteristic lesions in the placenta of pregnancies complicated by toxemia.
采用荧光抗体技术对17例足月妊娠合并妊娠中毒症的胎盘和17例正常对照胎盘进行了检测。使用了针对正常胎盘结缔组织和中毒胎盘结缔组织的抗血清。这些抗血清是通过将富含正常胎盘和中毒胎盘结缔组织成分的胎盘提取物注射到兔子体内获得的。抗中毒抗血清经正常胎盘可溶性超声破碎物吸收后，在17个胎盘中的14个胎盘中仅对以下成分染色：部分合体细胞结、血管外膜的纤维状成分以及结缔组织的无定形沉积物。在其余三个胎盘中，至少观察到了两种病变。在中毒胎盘的部分合体滋养层细胞和合体细胞结中观察到明亮荧光，这表明它们在疾病期间妊娠晚期出现。在中毒胎盘和正常胎盘中的不同发育阶段也记录到了细纤维状成分和结缔组织的无定形沉积物。这些发现确定了妊娠合并中毒症时胎盘可能存在的特征性病变。
