Ohlendieck K, Lennarz W J
Department of Pharmacology, University College Dublin, Belfield, Ireland.
Trends Biochem Sci. 1995 Jan;20(1):29-33. doi: 10.1016/s0968-0004(00)88947-1.
Embryonic development is initiated by a multi-step fertilization process involving induction of the acrosome reaction in sperm, sperm-egg binding, gamete membrane fusion and egg activation. In sea urchins, acrosome-reacted sperm interact, presumably via the sperm protein bindin, with a highly glycosylated receptor on the egg surface. This article highlights the recent advances in the molecular structure of the sea urchin sperm receptor and discusses its possible role in egg activation.
胚胎发育由一个多步骤的受精过程启动，该过程涉及精子顶体反应的诱导、精卵结合、配子膜融合和卵子激活。在海胆中，发生顶体反应的精子大概通过精子蛋白结合素与卵子表面一种高度糖基化的受体相互作用。本文重点介绍了海胆精子受体分子结构的最新进展，并讨论了其在卵子激活中的可能作用。
