• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Rapamycin (Sirolimus) inhibits vascular smooth muscle DNA synthesis in vitro and suppresses narrowing in arterial allografts and in balloon-injured carotid arteries: evidence that rapamycin antagonizes growth factor action on immune and nonimmune cells.

作者信息

Morris R E, Cao W, Huang X, Gregory C R, Billingham M E, Rowan R, Shorthouse R A

机构信息

Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA 94305-5247.

出版信息

Transplant Proc. 1995 Feb;27(1):430-1.

PMID:7879049
Abstract
摘要

相似文献

1
Rapamycin (Sirolimus) inhibits vascular smooth muscle DNA synthesis in vitro and suppresses narrowing in arterial allografts and in balloon-injured carotid arteries: evidence that rapamycin antagonizes growth factor action on immune and nonimmune cells.雷帕霉素（西罗莫司）在体外可抑制血管平滑肌的DNA合成，并可抑制同种异体动脉移植物和球囊损伤颈动脉的狭窄：这表明雷帕霉素可拮抗生长因子对免疫细胞和非免疫细胞的作用。
Transplant Proc. 1995 Feb;27(1):430-1.
2
Treatment with rapamycin blocks arterial intimal thickening following mechanical and alloimmune injury.雷帕霉素治疗可阻止机械性损伤和同种免疫损伤后动脉内膜增厚。
Transplant Proc. 1993 Feb;25(1 Pt 1):120-1.
3
Effects of treatment with cyclosporine, FK 506, rapamycin, mycophenolic acid, or deoxyspergualin on vascular muscle proliferation in vitro and in vivo.环孢素、FK 506、雷帕霉素、霉酚酸或去氧精胍菌素治疗对体外和体内血管平滑肌增殖的影响。
Transplant Proc. 1993 Feb;25(1 Pt 1):770-1.
4
Effects of rapamycin on growth factor-stimulated vascular smooth muscle cell DNA synthesis. Inhibition of basic fibroblast growth factor and platelet-derived growth factor action and antagonism of rapamycin by FK506.
Transplantation. 1995 Feb 15;59(3):390-5.
5
Effect of cyclosporine, mycophenolic acid, and rapamycin on the proliferation of rat aortic vascular smooth muscle cells: in vitro study.环孢素、霉酚酸和雷帕霉素对大鼠主动脉血管平滑肌细胞增殖的影响：体外研究
Transplant Proc. 2000 Nov;32(7):2026-7. doi: 10.1016/s0041-1345(00)01542-6.
6
Differential effects of modern immunosuppressive agents on the development of intimal hyperplasia.现代免疫抑制剂对内膜增生发展的不同影响。
Transpl Int. 2004 Jan;17(1):9-14. doi: 10.1007/s00147-003-0653-8. Epub 2003 Oct 10.
7
Endocardial mononuclear cell infiltrates (Quilty effect) in heterotopic cardiac allografts in rapamycin-treated rats.
Transplant Proc. 1994 Dec;26(6):3255-9.
8
Blockade of vascular smooth muscle cell proliferation and intimal thickening after balloon injury by the sulfated oligosaccharide PI-88: phosphomannopentaose sulfate directly binds FGF-2, blocks cellular signaling, and inhibits proliferation.硫酸化低聚糖PI - 88对球囊损伤后血管平滑肌细胞增殖和内膜增厚的抑制作用：硫酸化甘露五糖直接结合成纤维细胞生长因子-2，阻断细胞信号传导并抑制增殖。
Circ Res. 2003 May 2;92(8):e70-7. doi: 10.1161/01.RES.0000071345.76095.07. Epub 2003 Apr 10.
9
In vivo use of rapamycin suppresses neither IL-2 production nor IL-2 receptor expression in rat transplant model.在大鼠移植模型中，雷帕霉素的体内应用既不抑制白细胞介素-2的产生，也不抑制白细胞介素-2受体的表达。
Transplant Proc. 1993 Feb;25(1 Pt 1):723-4.
10
Rapamycin inhibits spontaneous and fibroblast growth factor beta-stimulated proliferation of endothelial cells and fibroblasts.
Transplant Proc. 1991 Dec;23(6):2833-6.

引用本文的文献

1
40 Years of Percutaneous Coronary Intervention: History and Future Directions.经皮冠状动脉介入治疗40年：历史与未来方向
J Pers Med. 2018 Oct 1;8(4):33. doi: 10.3390/jpm8040033.
2
Tailoring mTOR-based therapy: molecular evidence and clinical challenges.个体化 mTOR 靶向治疗：分子证据与临床挑战。
Pharmacogenomics. 2013 Sep;14(12):1517-26. doi: 10.2217/pgs.13.143.
3
Krüppel-like factor 4 is induced by rapamycin and mediates the anti-proliferative effect of rapamycin in rat carotid arteries after balloon injury.雷帕霉素诱导 Kruppel 样因子 4 的表达并介导其在大鼠颈动脉损伤后抗增殖作用。
Br J Pharmacol. 2012 Apr;165(7):2378-88. doi: 10.1111/j.1476-5381.2011.01734.x.
4
Vascular smooth muscle cell proliferation in restenosis.再狭窄中的血管平滑肌细胞增殖
Circ Cardiovasc Interv. 2011 Feb 1;4(1):104-11. doi: 10.1161/CIRCINTERVENTIONS.110.957332.
5
Low-dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor.低剂量口服西罗莫司可减少缺乏低密度脂蛋白受体的小鼠的动脉粥样硬化形成、血管炎症并调节斑块成分。
Br J Pharmacol. 2009 Mar;156(5):774-85. doi: 10.1111/j.1476-5381.2008.00080.x. Epub 2009 Feb 13.
6
Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin.核心蛋白聚糖介导的肾脏中纤连蛋白-1的调节涉及胰岛素样生长因子-I受体和雷帕霉素哺乳动物靶蛋白。
Am J Pathol. 2007 Jan;170(1):301-15. doi: 10.2353/ajpath.2007.060497.