Müller R, Steffen H M, Juretzko P, Bönner G, Krone W
Medizinische Klinik II, Universität Köln, Germany.
Angiology. 1995 Mar;46(3):221-8. doi: 10.1177/000331979504600305.
The sympathetic nervous system is unique in the regulation of plasma renin, for it can stimulate or suppress renin release by activation of either renal beta- or alpha 2-adrenoceptors. The authors studied plasma renin concentration (PRC), noradrenalin and adrenalin levels in plasma, and the densities of lymphocyte beta 2-adrenoceptors and thrombocyte alpha 2-adrenoceptors in 25 hypertensive patients with either normal (11-40 mU/L; n = 9) or low PRC (0-10 mU/L; n = 14). There were no differences in plasma catecholamine levels and adrenoceptor densities between the two patient groups. A positive correlation (r = 0.66; P < 0.005) between beta 2-adrenoceptor density and PRC in the patient group with low PRC, and a negative correlation (r = -0.72; P < 0.01) between alpha 2-adrenoceptor density and plasma renin in patients with normal PRC were found. They conclude that adrenoceptor densities on blood elements and plasma catecholamines do not differ in low and normal renin hypertension. The significant correlations between adrenoceptor densities and PRCs may indicate that adrenoceptors on blood elements mirror adrenoceptor densities in the kidney and that tonic suppression of renin release through alpha 2-adrenoceptors is preserved in hypertensive patients with normal plasma renin levels.
交感神经系统在血浆肾素的调节方面独具特色，因为它可通过激活肾β-肾上腺素能受体或α2-肾上腺素能受体来刺激或抑制肾素释放。作者研究了25例高血压患者的血浆肾素浓度（PRC）、血浆去甲肾上腺素和肾上腺素水平，以及淋巴细胞β2-肾上腺素能受体和血小板α2-肾上腺素能受体的密度，这些患者的PRC正常（11 - 40 mU/L；n = 9）或较低（0 - 10 mU/L；n = 14）。两组患者的血浆儿茶酚胺水平和肾上腺素能受体密度并无差异。在PRC较低的患者组中，β2-肾上腺素能受体密度与PRC呈正相关（r = 0.66；P < 0.005）；在PRC正常的患者中，α2-肾上腺素能受体密度与血浆肾素呈负相关（r = -0.72；P < 0.01）。他们得出结论，低肾素型和正常肾素型高血压患者血液成分上的肾上腺素能受体密度及血浆儿茶酚胺并无差异。肾上腺素能受体密度与PRC之间的显著相关性可能表明，血液成分上的肾上腺素能受体反映了肾脏中的肾上腺素能受体密度，并且在血浆肾素水平正常的高血压患者中，通过α2-肾上腺素能受体对肾素释放的紧张性抑制作用得以保留。
