Pfanner P, Marcheschi M
Istituto di Ricovero e Cura a Carattere Scientifico Stella Maris, Università degli Studi, Pisa.
Ann Ist Super Sanita. 1994;30(3):339-41.
Thyroid hormones play a key role in a number of critical neuromaturational processes, including neurogenesis, neuronal migration, synaptogenesis and myelination. Even in case of early treated CH children we cannot exclude the consequences of thyroid hormones deficiency in the critical pre and post-natal period. So, it is still useful to follow-up the neuropsychological development of CH children. IRCCS "Stella Maris" has been involved in research in this subject for several years with the collaboration the Institute of Endocrinology and of the Institute of Pediatrics (University of Pisa). According to our experience and to the results literature we propose to continue the follow-up studies with a simple, unique methodology that could be diffused to every screening center in Italy.
甲状腺激素在许多关键的神经成熟过程中发挥着关键作用,包括神经发生、神经元迁移、突触形成和髓鞘形成。即使对于早期接受治疗的先天性甲状腺功能减退症(CH)儿童,我们也不能排除在关键的产前和产后时期甲状腺激素缺乏所带来的后果。因此,对CH儿童的神经心理发育进行随访仍然是有必要的。多年来,IRCCS“斯特拉·马里思”医院在内分泌学研究所和儿科学研究所(比萨大学)的合作下参与了该主题的研究。根据我们的经验和文献结果,我们建议采用一种简单、统一的方法继续进行随访研究,这种方法可以推广到意大利的每个筛查中心。