Tsuruo T
Institute of Molecular and Cellular Biosciences, University of Tokyo.
Gan To Kagaku Ryoho. 1995 Feb;22(3):365-70.
P-glycoprotein plays a key role in the mechanisms of multidrug resistance in experimental tumors as well as in clinical tumors both in acquired and intrinsic-type resistance. Thus the therapeutic approaches targeting P-glycoprotein would provide benefits in eradication of drug-resistant tumor cells, although some potential problems concerning side effects still remain to be studied. Practical approaches to overcoming multidrug resistance by targeting the P-glycoprotein would be (1) to use antibodies against P-glycoprotein; and (2) to use agents, including calcium channel blocker-related agents and membrane-modifying agents, that interact with P-glycoprotein. These therapeutic approaches will be discussed in the symposium.
P-糖蛋白在实验性肿瘤以及临床肿瘤的多药耐药机制中，无论是获得性耐药还是固有性耐药，都起着关键作用。因此，针对P-糖蛋白的治疗方法在根除耐药肿瘤细胞方面将带来益处，尽管一些关于副作用的潜在问题仍有待研究。通过靶向P-糖蛋白来克服多药耐药的实际方法包括：（1）使用抗P-糖蛋白抗体；（2）使用与P-糖蛋白相互作用的药物，包括钙通道阻滞剂相关药物和膜修饰剂。这些治疗方法将在研讨会上进行讨论。
