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[一级蛋白质结构同源性的概率评估]

[Probabilistic evaluation of homology of primary protein structures].

作者信息

Ismailov I I, Sharov M V, Sharov M V, Bekmukhametova Z U

出版信息

Bioorg Khim. 1994 Nov;20(11):1150-61.

PMID:7880175
Abstract

Criteria have been developed for resemblance of segments of certain length of different proteins to be considered as an evidence of those proteins relationship. A table is formed of minimal numbers of identical amino acids for which the probability of the causal coincidence in a segment of certain length is less then 1%. The criteria were corroborated by comparison of natural proteins and model amino acid sequences concocted by means of the random numbers generator.

摘要

已经制定了相关标准,用于确定不同蛋白质特定长度片段的相似性,以此作为这些蛋白质之间存在关联的证据。通过构建一个表格,列出在特定长度片段中偶然出现相同氨基酸的最小数量,当这种偶然巧合的概率小于1%时,就可作为判断依据。通过对天然蛋白质和借助随机数生成器编造的模型氨基酸序列进行比较,证实了这些标准的有效性。

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