Scher M S
Developmental Neurophysiology Laboratory, Magee-Womens Hospital, Pittsburgh.
Pediatr Neurol. 1994 Oct;11(3):189-200. doi: 10.1016/0887-8994(94)90102-3.
Neonatal encephalopathies can be characterized in functional terms using electroencephalography. Severity of an encephalopathic state can also be estimated by electrographic interpretation independent of the time of disease process onset. Moderately or markedly abnormal electroencephalographic patterns on serial studies are highly correlated with neurologic sequelae in survivors. Electroencephalography is rarely pathognomonic or specific in determining when a condition initially occurred. However, electroencephalographic abnormalities are associated with different clinical situations, and brain lesions documented on neuroimaging or with postmortem neuropathologic examination are observed in infants with certain abnormal electrographic patterns. When interpreted in the context of history, clinical findings, and other laboratory information, the neurophysiologic studies augment the understanding of both the severity and timing of an encephalopathic state.
新生儿脑病可通过脑电图从功能角度进行特征描述。脑病状态的严重程度也可通过脑电图解读来估计，而与疾病过程开始的时间无关。系列研究中脑电图模式中度或明显异常与幸存者的神经后遗症高度相关。脑电图在确定病情最初发生时间方面很少具有确诊性或特异性。然而，脑电图异常与不同的临床情况相关，并且在具有某些异常脑电图模式的婴儿中观察到神经影像学记录的脑损伤或死后神经病理学检查结果。当结合病史、临床发现和其他实验室信息进行解读时，神经生理学研究有助于加深对脑病状态的严重程度和发生时间的理解。
