孕中期母体血清人绒毛膜促性腺激素水平低的临床意义
Clinical significance of low levels of second-trimester maternal serum human chorionic gonadotropin.
作者信息
Santolaya-Forgas J, Burd L I, Burton B K
机构信息
Department of Obstetrics and Gynecology, University of Illinois at Chicago.
出版信息
Fetal Diagn Ther. 1994 Nov-Dec;9(6):362-6. doi: 10.1159/000264066.
OBJECTIVE
To determine if unexplained low second-trimester maternal serum human chorionic gonadotropin (MShCG) is a useful predictor of complications of pregnancy.
STUDY DESIGN
Between 2/1/90 and 1/3/91, 3,116 patients underwent prenatal screening using second-trimester maternal serum alpha-fetoprotein (MSAFP), MShCG and maternal serum unconjugated estriol (MSuE3). Among these, there were 160 patients with complete obstetrical history who had second-trimester MShCG < 0.4 multiples of the median (MoM). These were compared to 261 controls with complete obstetrical history and a normal second-trimester MSAFP, MSuE3 and MShCG.
RESULTS
No differences were found in gestational age at delivery, neonatal weight, premature rupture of membranes or pregnancy loss. The relative risk of pregnancy-induced hypertension in the study group was 0.29 (p < 0.01) and that of gestational diabetes was 0.3 (p < 0.05). Only when low MShCG was associated with a high or low MSAFP or low MSuE3 was there a significantly increased loss of pregnancy (relative risk 11.7; p < 0.0001).
CONCLUSION
The data suggest that second-trimester MShCG < 0.4 MoM by itself has no influence on the outcome of pregnancy.
目的
确定孕中期母体血清人绒毛膜促性腺激素（MShCG）不明原因降低是否为妊娠并发症的有用预测指标。
研究设计
在1990年2月1日至1991年1月3日期间，3116例患者接受了孕中期母体血清甲胎蛋白（MSAFP）、MShCG和母体血清非结合雌三醇（MSuE3）的产前筛查。其中，160例有完整产科病史的患者孕中期MShCG低于中位数的0.4倍（MoM）。将这些患者与261例有完整产科病史且孕中期MSAFP、MSuE3和MShCG正常的对照组进行比较。
结果
在分娩孕周、新生儿体重、胎膜早破或妊娠丢失方面未发现差异。研究组妊娠高血压的相对风险为0.29（p<0.01），妊娠期糖尿病的相对风险为0.3（p<0.05）。仅当低MShCG与高或低MSAFP或低MSuE3相关时，妊娠丢失显著增加（相对风险11.7；p<0.0001）。
结论
数据表明，孕中期MShCG<0.4 MoM本身对妊娠结局无影响。
Zotero 插件