Jörgensen C, Andolf E
Department of Obstetrics and Gynecology, University Hospital Lund, Sweden.
Fetal Diagn Ther. 1994 Nov-Dec;9(6):395-7. doi: 10.1159/000264072.
Ductus venosus links the umbilical vein and the portal vein to the inferior vena cava. It is of great significance for the developing fetus but of minor importance to the growing infant where it normally obliterates and is transformed to the ligamentum venosum. An absent ductus venosus implies that the oxygenated blood from the umbilical vein has to circulate through the liver. We report 4 cases with this malformation. Prenatally, three fetuses had an extreme hydrops, especially hydrothorax. In two fetuses hydrops was severe already in the second trimester of pregnancy. Termination was performed. In the third case, hydrops was first diagnosed in the 36th week of gestation. The fourth case had an ultrasound examination in the 34th week of gestation. There was no hydrops but a disproportion with a very small head and abdominal diameter compared to femur length. Postpartum both these infants died. At autopsy, the only structural malformation in the three hydrops cases was an absent ductus venosus. In the fourth case there were other anomalies.
静脉导管将脐静脉与门静脉连接至下腔静脉。它对发育中的胎儿具有重要意义，但对成长中的婴儿来说重要性较小，在婴儿期它通常会闭塞并转化为静脉韧带。静脉导管缺如意味着来自脐静脉的氧合血必须通过肝脏循环。我们报告了4例这种畸形病例。产前，3例胎儿出现严重水肿，尤其是胸腔积液。2例胎儿在妊娠中期就已出现严重水肿，于是终止了妊娠。第3例在妊娠36周时首次诊断出水肿。第4例在妊娠34周时进行了超声检查，未发现水肿，但存在头围和腹径与股骨长度相比非常小的比例失调情况。产后这2例婴儿均死亡。尸检发现，3例水肿病例中唯一的结构畸形是静脉导管缺如。第4例还存在其他异常情况。
