中肠类癌综合征患者肝动脉栓塞后自然杀伤细胞的积聚
Accumulation of natural killer cells after hepatic artery embolisation in the midgut carcinoid syndrome.
作者信息
Wängberg B, Ahlman H, Tylén U, Nilsson O, Hermodsson S, Hellstrand K
机构信息
Department of Surgery, Sahlgrenska Hospital, Gothenburg, Sweden.
出版信息
Br J Cancer. 1995 Mar;71(3):617-8. doi: 10.1038/bjc.1995.120.
Abstract
Eleven patients with disseminated midgut carcinoid tumour disease were subjected to hepatic artery embolisation. In six patients, lymphocytosis with a predominance of NK cells occurred and the cytotoxic activity of isolated lymphocytes increased. A relation between NK cell accumulation and subsequent radiological and biochemical response was observed, and it is suggested that anti-tumour mechanisms other than ischaemia may contribute to the therapeutic response in these patients.
摘要
11例播散性中肠类癌肿瘤疾病患者接受了肝动脉栓塞术。6例患者出现淋巴细胞增多，其中NK细胞占优势，且分离出的淋巴细胞的细胞毒性活性增强。观察到NK细胞积聚与随后的放射学和生化反应之间存在关联，提示除缺血外的抗肿瘤机制可能有助于这些患者的治疗反应。
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