对抗菌制剂中使用的壬苯醇醚产生接触性光敏反应。
Contact photosensitivity to nonoxynol used in antiseptic preparations.
作者信息
Michel M, Dompmartin A, Moreau A, Leroy D
机构信息
Service de Dermatologie, Centre Hospitalier Universitaire, Caen, France.
出版信息
Photodermatol Photoimmunol Photomed. 1994 Oct;10(5):198-201.
Nonoxynols are nonionic surface-active agents used as surfactant in numerous cosmetic products and antiseptic preparations. Recently nonoxynol contact allergy has been described. We report two patients who presented a contact photosensitivity to nonoxynol 10 contained in Hexomédine transcutanée. Among 32 control subjects, we found 13 positive photopatch tests to Hexomédine transcutanée and 4 positive photopatch tests to nonoxynol 10. Surprisingly, the authors observed that only undiluted nonoxynol was phototoxic.
壬苯醇醚是非离子表面活性剂，在众多化妆品和防腐剂制剂中用作表面活性剂。最近已有壬苯醇醚接触过敏的报道。我们报告了两名对透皮六氯酚中含有的壬苯醇醚10产生接触性光敏感的患者。在32名对照受试者中，我们发现13人对透皮六氯酚光斑试验呈阳性，4人对壬苯醇醚10光斑试验呈阳性。令人惊讶的是，作者观察到只有未稀释的壬苯醇醚具有光毒性。
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