Okada H, Ishii K, Nunoki K, Taira N
Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
Biochim Biophys Acta. 1995 Mar 8;1234(1):145-8. doi: 10.1016/0005-2736(95)00015-u.
Recently, pIcln has been reported to be a regulator of a swelling-induced chloride conductance. We have cloned a cDNA RCL-H1 from rabbit heart, of which primary structure is highly homologous to that of pIcln. Outwardly rectifying currents were recorded in oocytes expressing RCL-H1, which is consistent with the result of pIcln. RNA blot analysis revealed the widespread expression of RCL-H1 mRNA in rabbit tissues. RCL-H1 may play an important role in regulating cell volume and give a clue to revealing molecular structure of swelling-induced chloride channel(s).
