Querleu D
Contracept Fertil Sex. 1995 Jan;23(1):29-36.
New data on the pathophysiology of pain associated with endometriosis are available. The predominant role of deep endometriosis has been stressed. In multivariate analysis, superficial endometriosis and even adhesions and ovarian cysts do not appear to be related with pain. Deep endometriosis is usually located posterior to the vagina and cervix, involving the pouch of Douglas, the rectovaginal septum and the uterosacral ligaments. In such cases, pelvic examination shows a painful induration or a nodule in this area. The anterior cul-de-sac and the lateral pelvic wall may also be involved. Two histological and clinical aspects may be observed: deep endometriosis arising under the peritoneal surface, or adenomyosis arising from the uterine cervix. Only complete surgical excision may be curative, but recurrences may occur after surgery. Hormonal therapy is only suspensive. However, surgical therapy involves a significant risk of complication. Surgery for deep endometriosis may be one of the most difficult gynecologic operations. It should be performed only by experienced surgeons, with skills in oncological dissections of the pelvis. The guidelines for therapy are thus clear. Superficial endometriosis does not cause pain and should not be treated by itself; symptomatic relief of pain may be obtained by therapeutic amenorrhea or by the placebo effect of surgery. Endometriomas are managed in the same way as all organic ovarian cysts. Adhesions are lysed if infertility is associated with pain, or to gain access to the retroperitoneal area. Etiologic therapy is acceptable only in case of deep endometriosis.(ABSTRACT TRUNCATED AT 250 WORDS)
关于子宫内膜异位症相关疼痛的病理生理学有了新数据。深部子宫内膜异位症的主要作用已得到强调。在多变量分析中,浅表性子宫内膜异位症甚至粘连和卵巢囊肿似乎与疼痛无关。深部子宫内膜异位症通常位于阴道和宫颈后方,累及直肠子宫陷凹、直肠阴道隔和子宫骶韧带。在这种情况下,盆腔检查会发现该区域有压痛性硬结或结节。前穹窿和盆腔侧壁也可能受累。可观察到两个组织学和临床方面:腹膜表面下出现的深部子宫内膜异位症,或源自子宫颈的子宫腺肌病。只有完全手术切除可能治愈,但术后可能复发。激素治疗只是暂时的。然而,手术治疗有显著的并发症风险。深部子宫内膜异位症手术可能是最困难的妇科手术之一。应由有经验的外科医生进行,他们需具备盆腔肿瘤解剖技能。因此,治疗指南很明确。浅表性子宫内膜异位症不会引起疼痛,不应单独治疗;可通过治疗性闭经或手术的安慰剂效应获得疼痛症状缓解。子宫内膜瘤的处理方式与所有器质性卵巢囊肿相同。如果不孕与疼痛相关或为了进入腹膜后区域,则松解粘连。仅在深部子宫内膜异位症的情况下病因治疗才是可接受的。(摘要截取自250字)