Rosay P, Hergueux J, Benoist C, Mathis D
Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS et INSERM U. 184, Institut de Chimie Biologique, Strasbourg, France.
C R Acad Sci III. 1994 Jul;317(7):639-43.
To investigate the capacity of class II gene products of the major histocompatibility complex to serve as targets for allograft rejection, we have used lines of transgenic mice which express such genes on a common genetic background. These lines allow us to test the function of single class II molecules, or of single chains of the class II heterodimers, in graft rejection or tolerance induction. Our data show that some class II molecules (A alpha, A beta) can induce very efficient rejection, while others are relatively inert (E), and that tolerance induction requires matching for both chains of the target class II heterodimers.
为了研究主要组织相容性复合体II类基因产物作为同种异体移植排斥反应靶标的能力，我们使用了在共同遗传背景下表达此类基因的转基因小鼠品系。这些品系使我们能够测试单个II类分子或II类异二聚体单链在移植排斥反应或耐受诱导中的功能。我们的数据表明，一些II类分子（Aα、Aβ）可诱导非常有效的排斥反应，而其他分子则相对无活性（E），并且诱导耐受需要靶II类异二聚体的两条链相匹配。
