细胞毒性T淋巴细胞相关抗原4（CTLA-4）可作为T细胞活化的负调节因子发挥作用。

CTLA-4 can function as a negative regulator of T cell activation.

作者信息

Walunas T L, Lenschow D J, Bakker C Y, Linsley P S, Freeman G J, Green J M, Thompson C B, Bluestone J A

机构信息

University of Chicago, Illinois 60637.

出版信息

Immunity. 1994 Aug;1(5):405-13. doi: 10.1016/1074-7613(94)90071-x.

DOI:10.1016/1074-7613(94)90071-x

PMID:7882171

Abstract

CD28 and CTLA-4 are related glycoproteins found on T cells. Ligation of CD28 following antigen receptor engagement provides a costimulatory signal required for T cell activation. Anti-CTLA-4 antibodies were generated to examine the role of the CTLA-4 receptor on murine T cells. Expression of CTLA-4 as a homodimer is up-regulated 2-3 days following T cell activation. Anti-CTLA-4 antibodies and Fab fragments augmented T cell proliferation in an allogeneic MLR. However, when optimal costimulation and Fc cross-linking were present, anti-CTLA-4 Mabs inhibited T cell proliferation. Together, these results suggest that the MAb may obstruct the interaction of CTLA-4 with its natural ligand and block a negative signal, or directly signal T cells to down-regulate immune function.

摘要

CD28和CTLA-4是在T细胞上发现的相关糖蛋白。抗原受体结合后CD28的连接提供了T细胞激活所需的共刺激信号。生成抗CTLA-4抗体以研究CTLA-4受体在小鼠T细胞上的作用。作为同源二聚体的CTLA-4的表达在T细胞激活后2-3天上调。抗CTLA-4抗体和Fab片段在同种异体混合淋巴细胞反应中增强了T细胞增殖。然而，当存在最佳共刺激和Fc交联时，抗CTLA-4单克隆抗体抑制T细胞增殖。总之，这些结果表明单克隆抗体可能阻碍CTLA-4与其天然配体的相互作用并阻断负信号，或直接向T细胞发出信号以下调免疫功能。