1型蛋白磷酸酶催化亚基同工型PP1γ1的表达增强与成骨性肿瘤的恶性程度相关。

Enhanced expression of catalytic subunit isoform PP1 gamma 1 of protein phosphatase type 1 associated with malignancy of osteogenic tumor.

作者信息

Sogawa K, Yamada T, Oka S, Kawasaki K, Mori S, Tanaka H, Norimatsu H, Cai Y, Kuwabara H, Shima H

机构信息

Department of Pathology, Kagawa Medical School, Japan.

出版信息

Cancer Lett. 1995 Feb 10;89(1):1-6. doi: 10.1016/0304-3835(95)90150-7.

DOI:10.1016/0304-3835(95)90150-7

PMID:7882291

Abstract

The expressions of the three catalytic subunits of protein phosphatase (PP) type 1 and 2A, PP1 alpha, PP1 gamma 1, and PP2AC, were examined in 14 cases of three types of osteogenic tumor using immunohistochemical analysis. The percentage of tumor cells stained positively with antiserum against PP1 catalytic subunit-isoform PP1 gamma 1 was significantly higher in malignant osteogenic tumors than in benign osteogenic tumors. Furthermore, malignant osteogenic tumor showed markedly high S-phase fraction in the cell cycle of tumor cells, as compared to benign osteogenic tumors. These results suggest that PP1 gamma 1 is involved in the accelerated growth of malignant cells in osteogenic tumors.

摘要

利用免疫组织化学分析法，对14例三种类型的成骨性肿瘤中蛋白磷酸酶（PP）1型和2A型的三种催化亚基，即PP1α、PP1γ1和PP2AC的表达情况进行了检测。与良性成骨性肿瘤相比，抗PP1催化亚基同工型PP1γ1抗血清染色呈阳性的肿瘤细胞百分比在恶性成骨性肿瘤中显著更高。此外，与良性成骨性肿瘤相比，恶性成骨性肿瘤在肿瘤细胞的细胞周期中显示出明显更高的S期比例。这些结果表明，PP1γ1参与了成骨性肿瘤中恶性细胞的加速生长。