Mardikar H M, Sahasrabhojaney V S, Jalgaonkar P D, Mahorkar U M, Mardikar M H, Waghmare B G
Department of Medicine, Govt. Medical College, Nagpur.
Indian J Med Res. 1995 Jan;101:25-7.
We studied the effect of atenolol 100 mg/day in 50 symptomatic patients of mitral stenosis and normal sinus rhythm, in a placebo controlled study. Atenolol caused significant bradycardia as compared to placebo (vitamin C; P < 0.001) without any adverse effects. It also increased exercise capacity significantly as compared to placebo (P < 0.001). All the patients were followed up to the period of 9 months and no adverse effects were seen. We conclude that beta adrenergic blocking drugs like atenolol can be used as the only treatment for patients with mitral stenosis without congestive heart failure and in sinus rhythm, for long-term symptomatic relief.
在一项安慰剂对照研究中，我们对50例有症状的二尖瓣狭窄且窦性心律正常的患者使用每天100毫克阿替洛尔进行了研究。与安慰剂（维生素C）相比，阿替洛尔引起了显著的心动过缓（P<0.001），且无任何不良反应。与安慰剂相比，它还显著提高了运动能力（P<0.001）。所有患者均随访9个月，未观察到不良反应。我们得出结论，像阿替洛尔这样的β肾上腺素能阻滞剂可作为无充血性心力衰竭且窦性心律的二尖瓣狭窄患者的唯一治疗药物，用于长期缓解症状。
