Kosako H, Gotoh Y, Nishida E
Department of Genetics and Molecular Biology, Kyoto University, Japan.
J Cell Sci Suppl. 1994;18:115-9. doi: 10.1242/jcs.1994.supplement_18.17.
In Xenopus oocytes, activation of MAP kinase occurs during meiotic maturation through a protein kinase cascade (the MAP kinase cascade), which is utilized commonly in various intracellular signaling pathways in eukaryotes. Studies with a neutralizing antibody against Xenopus MAP kinase kinase (MAPKK), a direct upstream activator for MAP kinase, have shown that the MAP kinase cascade plays a crucial role in both initiating oocyte maturation and inducing metaphase arrest.
