Cooke H J, Wang Y Z
Department of Physiology, Ohio State University, Columbus 43210.
J Auton Nerv Syst. 1994 Dec 15;50(2):201-7. doi: 10.1016/0165-1838(94)90010-8.
The role of H3 receptors in neurally-evoked recurrent increases in chloride ion secretion evaluated from changes in short-circuit current (Isc) was examined during application of histamine or histamine analogs. Muscle-stripped or whole thickness segments of distal colon were set up in flux chambers. Histamine and dimaprit, an H2 receptor agonist, caused recurrent increases in Isc. Dimaprit-evoked recurrent responses were reduced by the H3 receptor agonists, N alpha-methylhistamine and R alpha-methylhistamine, and the inhibition was reversed by the H3 receptor antagonist, burimamide. Histamine-evoked recurrent increases in Isc were enhanced by the H3 receptor antagonists burimamide and thioperamide. The results indicate that H3 receptors play an inhibitory role in histamine-evoked, neurally-mediated recurrent increases in Isc in guinea pig colon.
在应用组胺或组胺类似物期间，研究了H3受体在通过短路电流（Isc）变化评估的神经诱发的氯离子分泌反复增加中的作用。将远端结肠的肌层剥离或全层段置于通量室中。组胺和H2受体激动剂地马普明可引起Isc反复增加。H3受体激动剂Nα-甲基组胺和Rα-甲基组胺可减少地马普明诱发的反复反应，且H3受体拮抗剂布立马胺可逆转这种抑制作用。H3受体拮抗剂布立马胺和硫代哌酰胺可增强组胺诱发的Isc反复增加。结果表明，H3受体在豚鼠结肠中组胺诱发的、神经介导的Isc反复增加中起抑制作用。
