Przuntek H
Department of Neurology, Ruhr-University, Bochum, Federal Republic of Germany.
J Neural Transm Suppl. 1994;43:163-9.
Clinically a neuroprotective effect can only be presumed under the assumption that impairment of Parkinsonian symptoms, cellular dysfunction and cell degeneration are correlated. From the clinical point of view there is no real chance to demonstrate these correlations. For this reason it seems to be more realistic to differentiate between neuroprotective and functional neuroprotective effects. Bromocriptine as well as selegiline seem to have a functional neuroprotective effect.
临床上,只有在帕金森症状损害、细胞功能障碍和细胞变性相关的假设下,才能假定存在神经保护作用。从临床角度来看,没有实际机会证明这些相关性。因此,区分神经保护作用和功能性神经保护作用似乎更为现实。溴隐亭以及司来吉兰似乎具有功能性神经保护作用。