促甲状腺激素释放激素和去甲肾上腺素对新生和幼年小鼠体外吸气相关舌下运动神经元放电的增强作用。

Development of thyrotropin-releasing hormone and norepinephrine potentiation of inspiratory-related hypoglossal motoneuron discharge in neonatal and juvenile mice in vitro.

Funk G D, Smith J C, Feldman J L

Department of Physiological Science, University of California, Los Angeles 90024-1527.

J Neurophysiol. 1994 Nov;72(5):2538-41. doi: 10.1152/jn.1994.72.5.2538.

Abstract

The ontogeny of thyrotropin-releasing hormone (TRH) and norepinephrine (NE) potentiation of inspiratory-related hypoglossal (XII) motor nerve discharge was studied in medullary slices from P0-3, P7, and P11-14 mice that retain functional networks for respiration. 2. TRH, applied locally to the XII motor nucleus, had no effect on XII inspiratory burst amplitude in slices from P0-3 mice. By P7 there was significant potentiation of burst amplitude that increased more than three-fold by P11-14. NE applied to the XII nucleus produced significant potentiation in all age groups. Potentiation increased developmentally with the largest increase occurring between P0-3 and P7. 3. Thus catecholamine and TRH modulation of inspiratory-related XII nerve activity increases during the first two weeks of life; the potentiating effects of NE appear prior to those of TRH. 4. With rhythmically active, transverse medullary slices from mice up to 2 wk of age, it is now possible to study the development of XII motoneuron modulation as it relates to respiratory control of the upper airway.

摘要

研究了促甲状腺激素释放激素（TRH）和去甲肾上腺素（NE）对吸气相关舌下（XII）运动神经放电的增强作用在出生后0 - 3天、7天和11 - 14天小鼠延髓切片中的个体发生情况，这些小鼠保留了呼吸功能网络。2. 将TRH局部应用于XII运动核，对出生后0 - 3天小鼠的切片中XII吸气爆发幅度没有影响。到出生后7天，爆发幅度有显著增强，到出生后11 - 14天增加了三倍多。将NE应用于XII核在所有年龄组中都产生了显著增强作用。增强作用随发育而增加，最大的增加发生在出生后0 - 3天和7天之间。3. 因此，儿茶酚胺和TRH对吸气相关XII神经活动的调节在出生后的前两周增加；NE的增强作用先于TRH出现。4. 使用出生后2周龄以内小鼠有节律活动的横向延髓切片，现在有可能研究XII运动神经元调节的发育情况，因为它与上呼吸道的呼吸控制有关。