Büsche G, Buhr T, Georgii A
Pathologisches Institut, Medizinische Hochschule Hannover.
Pathologe. 1995 Jan;16(1):70-4. doi: 10.1007/s002920050078.
Histopathology of the bone marrow of diagnostic biopsies prior to any therapy is described in a total of 412 Ph1-positive patients. Special attention is paid to the distribution of megakaryocytes, increase of fibres and blasts, and occurrence of storing histiocytes of pseudo-Gaucher type. Megakaryocytes were significantly increased in 31.6% of diagnostic biopsies, myelofibrosis was found in 15.8%, significant increase of blasts in 2.4%. Pseudo-Gaucher cells were detected in 57.8% of a total of 412 biopsies. These histiological features are considered as an indication of the progress of the disease. A semiquantitative specification of CML by this criteria is described which can be performed rather reliably and defines the stage of CML at diagnosis prior to substantial treatment.
对412例Ph1阳性患者在任何治疗之前的诊断性活检骨髓组织病理学进行了描述。特别关注巨核细胞的分布、纤维和原始细胞的增加以及假性戈谢细胞型储存组织细胞的出现。在31.6%的诊断性活检中巨核细胞显著增加，15.8%发现骨髓纤维化，2.4%原始细胞显著增加。在412例活检中，57.8%检测到假性戈谢细胞。这些组织学特征被认为是疾病进展的指标。描述了根据该标准对慢性粒细胞白血病进行半定量分类的方法，该方法可相当可靠地进行，并在大量治疗之前确定慢性粒细胞白血病诊断时的阶段。
