Laviola G, Petruzzi S, Rankin J, Alleva E
Section of Behavioral Pathophysiology, Istituto Superiore di Sanità, Rome, Italy.
Pharmacol Biochem Behav. 1994 Dec;49(4):871-6. doi: 10.1016/0091-3057(94)90236-4.
The aim of the present report was to investigate the influence of pup stimulus properties and female parity on mouse maternal behavior. Outbred CD-1 mouse pups, prenatally exposed to either the vehicle (VEH) or oxazepam (OX, 15 mg/kg twice/day on pregnancy days 12-16) and fostered to untreated dams at birth, were offered as a stimulus on postnatal days 4, 6, and 8 to four groups of females that differed in maternal experience: virgin, experienced virgin females, primiparae, and biparae. Maternal behavior was observed during a 15-min session each day. Virgin females were less involved in crouching behavior than primiparae. Pups, age, and prenatal oxazepam showed interactive effects on maternal care, particularly by increasing licking and nest-building activities and decreasing still-out behavior. Moreover, dams receiving younger pups showed high levels of both locomotor activity and rearing. The present findings point to the need for a better understanding of mother-pup interactions in studies aimed at characterizing drug and toxicant effects on both animal and human development.
本报告的目的是研究幼崽刺激特性和雌性生育次数对小鼠母性行为的影响。将出生前暴露于赋形剂（VEH）或奥沙西泮（OX，妊娠第12 - 16天每天两次，每次15 mg/kg）并在出生时寄养给未处理母鼠的远交群CD - 1小鼠幼崽，在出生后第4、6和8天作为刺激物提供给四组具有不同母性经历的雌性小鼠：处女鼠、有经验的处女雌鼠、初产雌鼠和经产雌鼠。每天在15分钟的时间段内观察母性行为。处女雌鼠比初产雌鼠更少参与蹲伏行为。幼崽、年龄和产前奥沙西泮对母性关怀有交互作用，特别是通过增加舔舐和筑巢活动以及减少静止不动行为。此外，接受较年幼幼崽的母鼠表现出较高水平的运动活动和竖身行为。本研究结果表明，在旨在表征药物和毒物对动物和人类发育影响的研究中，需要更好地理解母婴互动。
