[治疗药物监测中水杨酸测定光度法的特殊资质]
[Special qualification of a photometric procedure for determination of salicylic acid in therapeutic drug monitoring].
作者信息
Martens J, Meyer F P
机构信息
Institut für Klinische Pharmakologie, Otto-von-Guericke-Universität Magdeburg.
出版信息
Pharmazie. 1995 Jan;50(1):41-3.
PMID:7886124
Abstract
A procedure for the determination of salicylic acid from human serum is presented. It is based on an acidic extraction, a basic reextraction and the detection of salicylic acid as its iron-III-complex by photometry. The procedure is quantitative over a wide range of linearity, easy to carry out and is especially suitable for therapeutic drug monitoring in the treatment of juvenile rheumatoid arthritis.
摘要
本文介绍了一种测定人血清中水杨酸的方法。该方法基于酸性萃取、碱性反萃取，并通过光度法检测水杨酸的铁（III）络合物。该方法在很宽的线性范围内具有定量性，易于操作，特别适用于青少年类风湿关节炎治疗中的治疗药物监测。
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