抗马来布鲁线虫IgG和IgG4血清学检测对班氏吴策线虫病诊断的阳性预测值较低。

Low positive predictive value of anti-Brugia malayi IgG and IgG4 serology for the diagnosis of Wuchereria bancrofti.

作者信息

Chanteau S, Glaziou P, Moulia-Pelat J P, Plichart C, Luquiaud P, Cartel J L

机构信息

Institut de Recherches Médicales Louis Malardé, Papeete-Tahiti, French Polynesia.

出版信息

Trans R Soc Trop Med Hyg. 1994 Nov-Dec;88(6):661-2. doi: 10.1016/0035-9203(94)90217-8.

DOI:10.1016/0035-9203(94)90217-8

PMID:7886763

Abstract

Enzyme-linked immunosorbent assays (ELISAs) for anti-Brugia malayi immunoglobulin (Ig) G and IgG4 were evaluated on sera from 1561 subjects in French Polynesia for the serodiagnosis of Wuchereria bancrofti filariasis, compared with the test for Onchocerca gibsoni circulating antigen (Og4C3) as a 'gold standard'. The sensitivity of the ELISA-IgG and ELISA-IgG4 assays was 90.8% and 94.5%, and the specificity was 45.9% and 50.7%. The positive predictive values were 41% and 45% respectively for an antigen prevalence rate of 30%. Thus antibody prevalences exceeded by two-fold the antigen prevalence, which itself exceeded by two-fold the prevalence of microfilaraemia.

摘要

在法属波利尼西亚，对1561名受试者的血清进行了抗马来布鲁线虫免疫球蛋白（Ig）G和IgG4的酶联免疫吸附测定（ELISA），用于班氏吴策线虫丝虫病的血清学诊断，并与作为“金标准”的吉氏盘尾丝虫循环抗原（Og4C3）检测进行比较。ELISA-IgG和ELISA-IgG4测定的灵敏度分别为90.8%和94.5%，特异性分别为45.9%和50.7%。对于30%的抗原流行率，阳性预测值分别为41%和45%。因此，抗体流行率超过抗原流行率两倍，而抗原流行率本身又超过微丝蚴血症流行率两倍。