Hopkins R J, Rothman M, Fiore A, Goldblum S E
Department of Medicine, University of Maryland School of Medicine, Baltimore.
Clin Infect Dis. 1994 Dec;19(6):1133-7. doi: 10.1093/clinids/19.6.1133.
We describe three cases of cerebral mucormycosis in intravenous drug users and review 22 previously reported cases. Involvement of the basal ganglia was demonstrated in all but two cases. Seven of the 10 patients tested for antibodies to the human immunodeficiency virus (HIV) were seronegative. Eight of the 25 patients survived and were discharged from the hospital; for 7 of 10 patients, cultures of brain lesions yielded Rhizopus arrhizus. The radiographic findings varied, and in most cases, no or minimal contrast enhancement was seen in the initial computed tomography scans. Although uncommon, the diagnosis of cerebral mucormycosis should be considered when basal ganglia lesions are present in an intravenous drug user, regardless of previous exposure to HIV.
我们描述了3例静脉吸毒者发生脑毛霉菌病的病例，并回顾了之前报道的22例病例。除2例病例外，其余所有病例均显示基底节受累。10例接受人类免疫缺陷病毒（HIV）抗体检测的患者中，7例血清学检测为阴性。25例患者中有8例存活并出院；10例患者中有7例脑病变培养出少根根霉。影像学表现各异，在大多数病例中，初次计算机断层扫描未见或仅见轻微对比增强。尽管罕见，但静脉吸毒者出现基底节病变时，无论之前是否接触过HIV，均应考虑脑毛霉菌病的诊断。
