Sharma R K, Kalla N R
Department of Biophysics, Panjab University, Chandigarh, India.
Int J Fertil Menopausal Stud. 1994 Nov-Dec;39(6):347-54.
To determine the (reversible) antifertility effect in the male rat of sulfasalazine, a common therapy for inflammatory bowel disease.
Sulfasalazine (120, 250 and 500 mg/kg) was administered for 60 days by oral gavage to sexually mature male rats.
Both motility of sperm and fertility of animals was significantly altered at the highest dose (500 mg/kg). Morphological abnormalities included alteration in the normal profile of the spermatozoa and presence of lesions on the sperm head.
Results suggest that sulfasalazine brings about its antifertility effects by altering sperm motility and number of spermatozoa in addition to increased surface abnormalities, which render the spermatozoa infertile.
确定柳氮磺胺吡啶（一种治疗炎症性肠病的常用药物）对雄性大鼠的（可逆性）抗生育作用。
通过口服灌胃对性成熟雄性大鼠给予柳氮磺胺吡啶（120、250和500毫克/千克），持续60天。
在最高剂量（500毫克/千克）时，精子活力和动物生育能力均发生显著改变。形态学异常包括精子正常形态改变以及精子头部出现损伤。
结果表明，柳氮磺胺吡啶通过改变精子活力、精子数量以及增加表面异常来发挥其抗生育作用，这些异常使得精子失去生育能力。
