Quessy S, Dubreuil J D, Higgins R
Groupe de Recherche sur les Maladies Infectieuses du Porc, Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec.
Can J Vet Res. 1994 Oct;58(4):299-301.
In this study, the IgG response of mice injected with two virulent strains and one avirulent Streptococcus suis capsular type 2 strain was compared by Western blotting. The serum from mice immunized against the avirulent strain could recognize most proteins of the various strains tested and similar results were obtained with serum from mice injected with virulent strains. The live avirulent strain was injected twice (days 0 and 10) to groups of five mice, and four virulent strains from different geographical origins were used to challenge the animals. All mice, except one in one group, survived the challenge. These results suggest that a live avirulent strain could be used for immunization of swine, the natural host.
在本研究中，通过蛋白质印迹法比较了注射两种强毒株和一种无毒猪链球菌2型菌株的小鼠的IgG反应。免疫无毒菌株的小鼠血清可识别所测试的各种菌株的大多数蛋白质，注射强毒株的小鼠血清也得到了类似结果。将活的无毒菌株分两次（第0天和第10天）注射给每组五只小鼠，并使用来自不同地理来源的四种强毒株对动物进行攻毒。除一组中的一只小鼠外，所有小鼠均在攻毒后存活。这些结果表明，活的无毒菌株可用于免疫猪这种天然宿主。
