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Translocation (1;14)(p34;q11) and trisomy 8 in a T-cell acute lymphoblastic leukemia patient.

作者信息

Martín-Henao G A, Sureda A

机构信息

Departamento de Hematología, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

出版信息

Cancer Genet Cytogenet. 1995 Feb;79(2):177-81. doi: 10.1016/0165-4608(94)00054-f.

DOI:10.1016/0165-4608(94)00054-f
PMID:7889516
Abstract

A case of T-cell acute lymphoblastic leukemia (T-ALL) in a 25-year-old man cytogenetically characterized by a t(1;14)(p34;q11) and trisomy 8 is reported. These chromosome abnormalities were observed in 82% of the analyzed metaphases. Fluorescence in situ hybridization (FISH) with a probe for the centromere of chromosome 8 was used to correlate cellular morphology in bone marrow (BM) cells with May-Grünwald-Giemsa smears and the cytogenetic alterations. By FISH analysis, trisomy 8 (and presumably the associated t[1;14]) was demonstrated only in lymphoid blast cells but not in the rest of the cells belonging to other hematopoietic lineages.

摘要

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