Dieter M P
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Environ Health Perspect. 1994 Nov;102 Suppl 7(Suppl 7):93-7. doi: 10.1289/ehp.94102s793.
Toxicity and potential carcinogenicity studies of boric acid were investigated in mice to verify in a second rodent species that this was a noncarcinogenic chemical. Earlier chronic studies in rats indicated boric acid was not a carcinogen. The chemical is nominated for testing because over 200 tons are produced annually, there are multiple uses for the product, and there is potential for widespread human exposure, both orally and dermally. Both sexes of B6C3F1 mice were offered diets mixed with boric acid for 14 days, 13 weeks, or 2 years. Dietary doses used in the acute, 14-day study were 0, 0.62, 1.25, 2.5, 5, and 10%; those in the subchronic, 13-week study were 0, 0.12, 0.25, 0.50, 1, and 2%; and doses in the 2-year, chronic study were 0, 0.25, and 0.50% in the diet. Mortality, clinical signs of toxicity, estimates of food consumption, body weight gain, and histopathologic examination of selected tissues constituted the variables measured. In the 14-day study mortality was proportional to dose and time of exposure in both sexes, occurring in dose groups as low as 2.5% and as early as 7 days of exposure. Body weights were depressed more than 10% below controls in the higher dose groups of both sexes. Mortality in the 13-week study was confined to the two highest dose groups in male mice and to the 2%-dose group in females. Body weight depression from 8 to 23% below those of controls occurred in the 0.50% and higher dose groups of both sexes.(ABSTRACT TRUNCATED AT 250 WORDS)
在小鼠身上进行了硼酸的毒性和潜在致癌性研究，以在第二种啮齿动物物种中验证其为非致癌化学物质。早期对大鼠的慢性研究表明硼酸不是致癌物。该化学品被指定进行测试，因为其年产量超过200吨，有多种用途，且存在通过口服和皮肤广泛接触人类的可能性。给B6C3F1小鼠的雌雄两性提供含硼酸的饲料，喂养14天、13周或2年。急性14天研究中使用的饲料剂量为0%、0.62%、1.25%、2.5%、5%和10%；亚慢性13周研究中使用的剂量为0%、0.12%、0.25%、0.50%、1%和2%；2年慢性研究中饲料中的剂量为0%、0.25%和0.50%。测量的变量包括死亡率、毒性临床体征、食物消耗量估计、体重增加以及对选定组织的组织病理学检查。在14天研究中，死亡率与剂量和暴露时间成正比，在雌雄两性中，低至2.5%的剂量组以及早在暴露7天时就出现死亡。在雌雄两性的高剂量组中，体重比对照组低10%以上。在13周研究中，死亡率仅限于雄性小鼠的两个最高剂量组和雌性小鼠的2%剂量组。在雌雄两性中，0.50%及以上剂量组的体重比对照组低8%至23%。（摘要截短至250字）
