Fruzzetti F, De Lorenzo D, Ricci C, Teti G
Department of Obstetrics and Gynecology, University of Pisa, Italy.
Fertil Steril. 1995 Apr;63(4):734-41. doi: 10.1016/s0015-0282(16)57474-3.
To determine whether the ovary influences adrenal androgen secretion in polycystic ovary syndrome (PCOS).
The adrenal androgen secretion was evaluated before and during ovarian suppression with a long-acting GnRH agonist.
Department of Obstetrics and Gynecology, Pisa, Italy.
Women with PCOS and high (10 subjects) and normal (12 subjects) DHEAS levels and 6 normal women.
After 1 mg dexamethasone, an ACTH-(1-24) stimulation test was performed in the early follicular phase of the menstrual cycle. The test was repeated after two injections of a long-acting GnRH analogue (GnRH-a).
Basal plasma levels of gonadotropins, E2, T, androstenedione (A), 17 alpha-hydroxyprogesterone (17-OHP), DHEAS, and cortisol (F) were evaluated before the evening administration of dexamethasone. Serum A, T, 17-OHP, DHEAS, and F were measured 9 hours after dexamethasone and in samples collected 60 and 120 minutes after ACTH IV injection.
In the high DHEAS group the maximum increases in T, A, 17-OHP, and DHEAS in response to ACTH were significantly higher than in normal DHEAS PCOS women and in normal women. The GnRH-a modified the A and T responses to ACTH in the high DHEAS group.
Ovarian steroids, or other extra-ovarian factors, seem to be responsible for the increased A and T responses to the corticotropin stimulation demonstrated in some PCOS women.
确定卵巢是否影响多囊卵巢综合征（PCOS）患者的肾上腺雄激素分泌。
使用长效GnRH激动剂在卵巢抑制前后评估肾上腺雄激素分泌。
意大利比萨妇产科。
PCOS患者，其中硫酸脱氢表雄酮（DHEAS）水平高的有10名受试者，水平正常的有12名受试者，以及6名正常女性。
在月经周期的卵泡早期，给予1mg地塞米松后，进行促肾上腺皮质激素（ACTH）-（1-24）刺激试验。在注射两次长效GnRH类似物（GnRH-a）后重复该试验。
在晚上给予地塞米松前，评估促性腺激素、雌二醇（E2）、睾酮（T）、雄烯二酮（A）、17α-羟孕酮（17-OHP）、DHEAS和皮质醇（F）的基础血浆水平。在给予地塞米松9小时后以及静脉注射ACTH后60和120分钟采集的样本中测量血清A、T、17-OHP、DHEAS和F。
在高DHEAS组中，ACTH刺激后T、A、17-OHP和DHEAS的最大增幅显著高于正常DHEAS的PCOS女性和正常女性。GnRH-a改变了高DHEAS组中ACTH刺激后的A和T反应。
卵巢类固醇或其他卵巢外因素似乎是导致部分PCOS女性对促肾上腺皮质激素刺激的A和T反应增加的原因。
