Riikonen R
Department of Child Neurology, Children's Hospital, Helsinki, Finland.
Dev Med Child Neurol. 1995 Mar;37(3):232-8. doi: 10.1111/j.1469-8749.1995.tb11997.x.
The present study examined whether changes in the incidence of infantile spasms could be used to evaluate changes in the quality of pre- and perinatal care over time. 107 children in 1960 to 1976, and 102 in 1977 to 1991, developed infantile spasms in southern Finland. The number of small-for-gestational age (SGA) infants and infants with neonatal hypoglycaemia decreased significantly. Brain malformations, malformation syndromes and patients with tuberous sclerosis increased; this probably reflects the development of more refined neuroradiological screening methods. SGA infants are probably more apt to develop infantile spasms than preterm infants appropriate for gestational age. Early prenatal factors seem to play a major role in the genesis of infantile spasms. Little can be done to reduce the incidence of infantile spasms, but every effort should be made to reduce the number of SGA infants by good prenatal care. Treatment of hypoglycaemia is important because infantile spasms might be preventable in these infants.
本研究探讨了婴儿痉挛症发病率的变化是否可用于评估不同时期围产期保健质量的变化。在芬兰南部，1960年至1976年间有107名儿童患婴儿痉挛症，1977年至1991年间有102名。小于胎龄儿（SGA）和新生儿低血糖患儿的数量显著减少。脑畸形、畸形综合征和结节性硬化症患者增加；这可能反映了更精细的神经放射学筛查方法的发展。SGA婴儿可能比适于胎龄的早产儿更容易发生婴儿痉挛症。早期产前因素似乎在婴儿痉挛症的发病中起主要作用。降低婴儿痉挛症发病率的措施有限，但应通过良好的产前保健尽一切努力减少SGA婴儿的数量。低血糖的治疗很重要，因为这些婴儿的婴儿痉挛症可能是可预防的。
